Rajasree, K; Ravi Kumar, A V; Radhakrishnan, P; Nampoori, V P N; Vallabhan, C P G(Springer, April , 1992)
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Abstract:
Photothermal deflection technique was used for determining the laser damage threshold of polymer samples of teflon (PTFE) and nylon. The experiment was conducted using a Q-switched Nd-YAG laser operating at its fundamental wavelength (1-06μm, pulse width 10 nS FWHM) as irradiation source and a He-Ne laser as the probe beam, along with a position sensitive detector. The damage threshold values determined by photothermal deflection method were in good agreement with those determined by other methods.
Ramachandran, A; Jameela Beevi, K S(April 30, 2003)
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Abstract:
While conducting surveys for potential ornamental fishes in the fresh water bodies
of the river Periyar, three specimens of Danio fraseri Hora and Mukerji, were collected from a
stream joining to the river Periyar, at Desom, near Alwaye on 6 October 2001. It is the only
species so far known under the genus Danio with a hypertrophied lower lip forming a loose
flap along the lower jaw. This is a new locality record for Kerala and southern Western
Ghats.
Sindhu, M S; Dr.Kannan, B(Cochin University of Science And Technology, July 23, 2013)
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Abstract:
In the current study, epidemiology study is done by means of
literature survey in groups identified to be at higher potential for DDIs as
well as in other cases to explore patterns of DDIs and the factors affecting
them. The structure of the FDA Adverse Event Reporting System (FAERS)
database is studied and analyzed in detail to identify issues and challenges
in data mining the drug-drug interactions. The necessary pre-processing
algorithms are developed based on the analysis and the Apriori algorithm is
modified to suit the process. Finally, the modules are integrated into a tool to identify DDIs. The results are compared using standard drug interaction
database for validation. 31% of the associations obtained were identified to
be new and the match with existing interactions was 69%. This match
clearly indicates the validity of the methodology and its applicability to
similar databases. Formulation of the results using the generic names
expanded the relevance of the results to a global scale. The global
applicability helps the health care professionals worldwide to observe
caution during various stages of drug administration thus considerably
enhancing pharmacovigilance
Description:
Department of Computer Applications, Cochin
University of Science and Technology
Varghese, Paul; Dr.Poulose Jacob, K(Cochin University of Science & Technology, April , 2003)
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Abstract:
The present research problem is to study the existing encryption
methods and to develop a new technique which is performance wise
superior to other existing techniques and at the same time can be very
well incorporated in the communication channels of Fault Tolerant
Hard Real time systems along with existing Error Checking / Error
Correcting codes, so that the intention of eaves dropping can be
defeated. There are many encryption methods available now. Each
method has got it's own merits and demerits. Similarly, many crypt
analysis techniques which adversaries use are also available.
Description:
Department of Computer Science, Cochin University of Science and
Technology
Sonal Kumar, Jain; Dr.Anil, Bhardwaj(Cochin University Of Science And Technology, January , 2013)
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Abstract:
An attempt has been made in this thesis to model some of the emissions observed
by SPICAM and SPICAV on Mars and Venus, respectively, viz., CO Cameron band,
CO+
2 ultraviolet doublet, N2 triplet bands, atomic oxygen green (5577 A), red doublet
(6300, 6364 A), and ultraviolet (2972 A) emissions. One of major sources of these
emissions is photoelectron impact ionization/excitation. In this thesis, an electron
degradation model based on Monte Carlo technique has been developed to calculate
the production/excitation rates of above mentioned emissions due to electron impact.
The limb brightness pro les of emissions are calculated and compared with the observations
wherever available. The e ect of various model input parameters on dayglow
emissions intensities is also evaluated
Description:
Space Physics Laboratory
Vikram Sarabhai Space Centre
Indian Space Research Organisation
Thiruvananthapuram
Syamaprasad, U; Vallabhan, C P G(Institute of Physics, 1981)
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Abstract:
Four distinct peaks are observed at 140, -26, -132 and -140°C in the sigma x* against T-1 plot between 200 and - 196°C for (NH4)3H(SO4)2, corresponding to four different phase
transitions of which the one at -26°C is reported here for the first time. Data on doped
samples reveal the charge transport mechanism in the crystal.
Poulose Jacob,K; Shahana, T K; Rekha, James K; Sreela Sasi(IEEE, December 1, 2008)
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Abstract:
Decimal multiplication is an integral part offinancial,
commercial, and internet-based computations. The basic
building block of a decimal multiplier is a single digit
multiplier. It accepts two Binary Coded Decimal (BCD)
inputs and gives a product in the range [0, 81] represented
by two BCD digits. A novel design for single digit decimal
multiplication that reduces the critical path delay and area
is proposed in this research. Out of the possible 256
combinations for the 8-bit input, only hundred
combinations are valid BCD inputs. In the hundred valid
combinations only four combinations require 4 x 4
multiplication, combinations need x multiplication,
and the remaining combinations use either x or x
3 multiplication. The proposed design makes use of this
property. This design leads to more regular VLSI
implementation, and does not require special registers for
storing easy multiples. This is a fully parallel multiplier
utilizing only combinational logic, and is extended to a
Hex/Decimal multiplier that gives either a decimal output
or a binary output. The accumulation ofpartial products
generated using single digit multipliers is done by an array
of multi-operand BCD adders for an (n-digit x n-digit)
multiplication.
Description:
Electronic Design, 2008. ICED 2008. International Conference on
Poulose Jacob,K; Sreela Sasi; Babita, Jose R; Shahana, T K(International Journal of Signal Processing, April 1, 2009)
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Abstract:
The demand for new telecommunication services
requiring higher capacities, data rates and different operating modes
have motivated the development of new generation multi-standard
wireless transceivers. A multi-standard design often involves
extensive system level analysis and architectural partitioning,
typically requiring extensive calculations. In this research, a
decimation filter design tool for wireless communication standards
consisting of GSM, WCDMA, WLANa, WLANb, WLANg and
WiMAX is developed in MATLAB® using GUIDE environment for
visual analysis. The user can select a required wireless
communication standard, and obtain the corresponding multistage
decimation filter implementation using this toolbox. The toolbox
helps the user or design engineer to perform a quick design and
analysis of decimation filter for multiple standards without doing
extensive calculation of the underlying methods.
Description:
World Academy of Science, Engineering and Technology
Vol:3 2009-11-22
Eswar Shankar,P N; Anu, Joseph; Paulose,C S(Department of Biotechnology, May 17, 2006)
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Abstract:
In the present study dopamine was measured in the hypothalamus, brainstem, pancreatic islets and plasma, using HPLC. Dopamine D2 receptor
changes in the hypothalamus, brainstem and pancreatic islets were studied using [3H] YM-09151-2 in streptozotocin-induced diabetic and insulintreated
diabetic rats. There was a significant decrease in dopatnine content in the hypothalamus (P<0.001), brainstem (P<0.001), pancreatic islets
(P<0.001) and plasma (P<0.00I) in diabetic rats when compared to control. Scatchard analysis of [3H] YM-09151-2 in the hypothalamus of
diabetic rats showed a significant decrease in Bax (P<0.001) and Kd, showing an increased affinity of D2 receptors when compared to control.
Insulin treatment did not completely reverse the changes that occurred during diabetes. There was a significant decrease in B,nax (P<0.01) with
decreased affinity in the brainstem of diabetic rats. The islet membrane preparation of diabetic rats showed a significant decrease (P<0.001) in the
binding of [3H] YM-09 151-2 with decreased Kd (P<0.001) compared to control. The increase in affinity of D2 receptors in hypothalamus and
pancreatic islets and the decreased affinity in brainstem were confirmed by competition analysis. Thus our results suggest that the decreased
dopamine D, receptor function in the hypothalamus, brainstem and pancreas affects insulin secretion in diabetic rats, which has immense clinical
relevance to the management of diabetes.
Mohanan,Valiyaveettil; Balarama Kaimal,S; Paulose, Cheramadathikudyil S(Department of Bio Technology, August 30, 2004)
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Abstract:
The present study was to investigate the rote of central 5-11T and 5-HT,:v receptor Lindin4o
and acne expression in it 'at mo(lel of pancreatic regeneration using 60" -, pancreatcutumy.
The pancreatic regeneration was evaluated by 5-HT content and 5-HT,,receptor gene
expression in the cerebral cortex (CC) and brain stem MS) of Alain opcrate,t, 7 It utd
7 (.lays panereatectomised rats. 5-11T content significantly increased in the CC' (I' 1.1)11
and 13S (P 0.05) of 72 Ii p.ntcreateetomiscd rats. Sympathetic activity was decreased as
indicated by the significantly decreased norcpiuephrine (NIi) and epinephrine (FTI) Icvcl
(1' < 0.001 and P < 0.05) in the plasma of 72 h panereateetomised rats. 5-111 ,^, receptor
density and affinity was decreased in the CC (P < 0.01) and BS (P < 0.01). These rh:)nge;
correlated with a diminished 5-IITIA receptor mRNA expression in the brain region. studied.
Our resuils suggest that the brain 5-11T through 5-HTin receptor has it funcuon:0 rule
iii 11w pi+ncreatic regcner:ttion through the sympathetic regulation.
Mohanan,Valiyaveettil; Finla, Chathu; Paulose, Cheramadathikudyil S(Department of Bio Technology, December 1, 2004)
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Abstract:
The purpose of this study was to investigate the role of central 5-HT2C receptor binding in rat model of pancreatic regeneration
using 60-70% pancreatectomy. The 5-HT and 5-HT2c receptor kinetics were studied in cerebral cortex and brain stem of sham
operated, 72 h pancreatectomised and 7 days pancreatectomised rats. Scatchard analysis with [3H] mesulergine in cerebral
cortex showed a significant decrease (p < 0.05) in maximal binding (B^,ax) without any change in Kd in 72 h pancreatectomised
rats compared with sham. The decreased Bmax reversed to sham level by 7 days after pancreatectomy. In brain stem , Scatchard
analysis showed a significant decrease (p < 0.01) in Bax with a significant increase (p < 0.01) in Kd. Competition analysis
in brain stem showed a shift in affinity towards a low affinity. These parameters were reversed to sham level by 7 days after
pancreatectomy. Thus the results suggest that 5-HT through the 5-HT2C receptor in the brain has a functional regulatory role in
the pancreatic regeneration. (Mol Cell Biochem 272: 165-170, 2005)
Ani Das, V; Finla, Chathu; Paulose,C S(Department of Bio Technology, April 20, 2006)
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Abstract:
Sympathetic stimulation inhibits insulin secretion. a2-Adrenergic receptor is known to have a regulatory role in the sympathetic function. We
investigated the changes in the a2-adrenergic receptors in the brain stein and pancreatic islets using [3H]Yohimbine during pancreatic regeneration
in weanling rats. Brain stem and pancreatic islets of experimental rats showed a significant decrease (p<0.001) in norepinephrine (NE) content at
72 h after partial pancreatectomy. The epinephrine (EPI) content showed a significant decrease (p<0.001) in pancreatic islets while it was not
detected in brain stem at 72 h after partial pancreatectomy. Scatchard analysis of [3H]Yohimbine showed a significant decrease
(p<0.05) and Kd at 72 h after partial pancreatectomy in the brain stem. In the pancreatic islets, Scatchard analysis of [3H]Yohimbine showed a signiinfiBca'nnatx
decrease (p<0.001) in B,nax and Kd (p<0.05) at 72 h after partial pancreatectomy. The binding parameters reversed to near sham by 7 days after
pancreatectomy both in brain stein and pancreatic islets. This shows that pancreatic insulin secretion is influenced by central nervous system inputs
from the brain stem. In vitro studies with yohimbine showed that the a2-adrenergic receptors are inhibitory to islet DNA synthesis and insulin
secretion. Thus our results suggest that decreased a2-adrenergic receptors during pancreatic regeneration functionally regulate insulin secretion
and pancreatic 13-cell proliferation in weanling rats.
Paulose,C S; Peeyush, K T; Anju, T R(Springer Science+Business Media, LLC 2009, 2009)
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Abstract:
Hypoxia in neonates can lead to biochemical
and molecular alterations mediated through changes in
neurotransmitters resulting in permanent damage to brain.
In this study, we evaluated the changes in the receptor
status of GABAA in the cerebral cortex and brainstem of
hypoxic neonatal rats and hypoxic rats supplemented with
glucose and oxygen using binding assays and gene
expression of GABAAa1 and GABAAc5. In the cerebral
cortex and brainstem of hypoxic neonatal rats, a significant
decrease in GABAA receptors was observed, which
accounts for the respiratory inhibition. Hypoxic rats sup-
plemented with glucose alone and with glucose and oxygen
showed, respectively, a reversal of the GABAA receptors,
andGABAAa1 and GABAAc5 gene expression to control.
Glucose acts as an immediate energy source thereby
reducing the ATP-depletion-induced increase in GABA
and oxygenation, which helps in encountering anoxia.
Resuscitation with oxygen alone was less effective in
reversing the receptor alterations. Thus, the results of this
study suggest that reduction in the GABAA receptors
functional regulation during hypoxia plays an important
role in mediating the brain damage. Glucose alone and
glucose and oxygen supplementation to hypoxic neonatal
rats helps in protecting the brain from severe hypoxic
damage.
Balarama Kaimal,S; Gireesh,G; Paulose,C S(Department of Biotechnology, January 4, 2007)
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Abstract:
Gamma amino outyric acid is a major
inhibitory neurotrarsr titter in the central nervous
system. In the preset study sv, Have investigate(' the
alteration of GABA receptor, In t he hrain stem of rats
during pancreatic regeneration. Three groups of rats
were used for the study: sham operated, 72 It and
7 days partially pancreatectonnsea. GABA was (juan-
(ified by [H]GABA receptor iispiacement method.
GABA receptor kin: 10, pat at i et•ers were studied by
using the binding of F'.](iAhA as ligand to the Triton
X-100 treated me,i1,;-:mes a1,J displacement with
unlabelled GABA. GhRA,v receptor activity was
studied by using the [` -1 h3cuculline and displacement
with unlabellecV euculline. ;.\13A content significantly
decreased (1' < (1.(101 ) it, 0-e brain stern during
the regeneration of pancreas. 'I hl, high affinity (IAI3A
receptor binding sho?:ed it sigii'f cant decrease in 131„.,\
(P < 11.01) and K,I 1).05) n 72 h and 7 days after
partial pancreatee 'timv. ";:flhicuculline hin(Iing
showed it signih eat, 'le ( r(, :,e in /Jn1,s and K,I
(P < 0.001) in 72 h pa^.rcreaw,, mised rats when compared
with sham wt--tt' as P,n and K,I reversed to
near sham after 7 da,s of pancreatectomv. The results
sugge,) that GAB A throur,r; ('GABA receptors in
brain Atcem has a regulatory uie during active regeneration
of pancreas which will have inunense clinical
significance in the treatment of cliahetcs.
Ani Das, V; Savitha,B; Paulose,C S(Department of Biotechnology, April 4, 2006)
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Abstract:
purpose of this study was to investigate the
role of brain al-adrenergic receptor binding in the rat model
of pancreatic regeneration using 60-70% pancre:dectorny.
The a, -adrenergic receptors kinetics was studied in the
cerebral cor:cx and brain stem of sham operated . 72 It pan-
crea(ectoinised and 7 days pancreatectomised rats. Scar
chard analysis with I `I I lprazocin in cerebral cartes and brain
stein showed a significant decrease (/' < 0.01). (P < 0.05)
in maximal binding ( 1),,,,,) with it significant decrease
(P < 0.001 ), ( P < 0.01) in the K,,in 72 It pancreatecto-
raised rats compared with sham , respectively . Competition
analysis in cerebral cortex and brain stem showed it shift in
affinity during pancreatic regeneration . The sympathetic
activity was decreased as indicated by the significantly de-
increased norepinephrine level in the plasma (P < 0.001),
cerebral cortex (P < 0.01) and brain stem (P < 0.001) of
72 h pancreatectomised rats compared to sham . Thus, from
our results it is suggested that the central a, -adrenergic
receptors have a functional role in the pancreatic regenera-
Lion mediated through the sympathetic pathway.