A series of novel naphthyridine derivatives 3
and 4 was prepared from substituted pyridine 2 and ketones
using ZnCl2 as catalyst under microwave irradiation conditions.
All the compounds were evaluated for AChE
inhibitory activity and promising compounds 3d, 3e, 4b,
and 4g was identified. Representative compounds 3d and
3e were found to show insignificant THLE-2 liver cell
viability/toxicity. The binding mode between X-ray crystal
structure of human AChE and compounds was studied
using molecular docking method and fitness scores were
found to be in good correlation with the activity data.
Description:
Med Chem Res (2012) 21:1785–1795
DOI 10.1007/s00044-011-9695-0