Dipyrromethene-Cu(II) derivatives possessing two dodecane alkyl chains have been used for the modification of gold
electrodes. Electroactive host molecules have been incorporated into a lipophilic dodecanethiol SAM deposited onto
gold electrodes through hydrophobic and van der Waals interactions (embedment technique). The presence of
dipyrromethene-Cu(II) redox centers on the electrode surface was proved by cyclic voltammetry and Osteryoung
square-wave voltammetry. The Au electrodes incorporating redox active Cu(II)-dipyrromethene SAMs were used for
the direct voltammetric determination of paracetamol in human plasma.